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Clinical studies have provided strong evidence about GLP-1 safety

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Clinical trials (ten studies, 419 participants) using doses from 400 mg to 10 g over 21 days to 20 months show consistent reductions in fasting glucose, post-meal glucose, and HbA1c. In diabetic animal studies, gymnema increased proglucagon gene expression (a precursor for GLP-1) and insulin gene activity, suggesting it may help amplify endogenous GLP-1 production

Open access peer-reviewed chapter

Calocurb has shown a low incidence of side effects in studies but mild effects can persist within the first 24-72 hours