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To address this challenge, we sought to develop long-acting formulations of semaglutide and liraglutide providing continuous therapy for upwards of four months from a single administration to coincide with the typical cadence with which T2D patients visit their endocrinologist or primary care provider (Figure 1B and C) ( 27 )

The neuroprotective potential of GLP-1 has been established in models of neurodegenerative disorders, including Parkinsons disease and Alzheimers disease (AD), with evidence suggesting it can modify disease progression and ameliorate pathology [2932]

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Des donnes limites sur les expositions involontaires aux GLP1-RA en dbut de grossesse (au moins 500 grossesses) ne suggrent pas de risque accru de malformations congnitales par rapport aux grossesses prsentant des conditions similaires