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To ensure that [] weight reduction is caused primarily by a reduction in fat content, not lean body mass, a representative sample of trial subjects should have a baseline and follow-up measurement of body composition by DXA or a suitable alternative. When undue muscle loss becomes a problem Sarcopenia, the progressive, aging-related loss of muscle, contributes to the development of physical frailty, including weakness, fatigue and balance problems which limit a persons mobility and increase the risk of falls, fractures and other serious injuries

Upper respiratory tract and urinary tract infections were reported with GLP-1 RA use, with influenza, cystitis, nasopharyngitis, and viral infections being most common in their individual trials

They cause weight loss at a scale hitherto unknown in the modern medical era

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Mirikizumab regulates genes involved in ulcerative colitis disease activity and anti-TNF resistance: results from a phase 2 study