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Change from Week -12 is not a primary endpoint in Study 3

Potential Causes of Muscle Aches During Treatment One of the most frequent causes of muscle discomfort while taking GLP-1 or GIP medications is dehydration

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If your drug levels are fluctuating due to irregular injection intervals, your appetite suppression will be inconsistent, your eating patterns will be inconsistent, and your caloric intake will vary unpredictably from week to week

If semaglutide caused severe nausea before slowing the dose increase might help