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If you experience persistent or severe fatigue, discuss it with your healthcare provider to rule out other causes, such as hypoglycemia or other medical issues
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However, a recent retrospective cohort study, which included 240,618 overweight or obese patients who were prescribed either semaglutide, or non-GLP1R-agonist anti-obesity medications, did not find increased risk of suicidal ideation with semaglutide use (136)
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Future studies are needed to elucidate further the connections between the ghrelin system, metabolism and circadian systems, and to provide novel avenues for therapeutic approaches
