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Semaglutide , taken weekly: Possibly the most well-known of them all, FDA-approved under the brand names Ozempic for type 2 diabetes and to reduce the risk of a major adverse cardiovascular event in adults with type 2 diabetes or an established cardiovascular disease and Wegovy for obesity

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Glucagon-like peptide-1 attenuates endothelial barrier injury in diabetes via cAMP/PKA mediated down-regulation of MLC phosphorylation

subsequent preclinical studies have thus screened agonists with primates with Trp33 ECD or receptor mutants with substitution of Ser33 ECD by Trp33 ECD

Its called a triple agonist because it acts on three hormones: GLP-1, GIP and glucagon