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You should not take a GLP-1 drug if you have severe gastrointestinal conditions like inflammatory bowel disease (IBD) or gastroparesis or a personal or family history of multiple endocrine neoplasia 2A, multiple endocrine neoplasia 2B, medullary thyroid cancer, or pancreatitis

11/03/2025 Electronic publication Footnotes Conflict of interest: DJD has received consulting fees from Anylam, Amgen, AstraZeneca Inc., Crinetics, Eli Lilly, Insulet, Kallyope, Metsara, and Pfizer Inc

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It can be frustrating to dedicate time, effort, and energy into lifestyle changes only to see minimal progress

If dietary sources prove insufficient, healthcare professionals may recommend fibre supplements such as psyllium or methylcellulose, though these should be introduced under medical supervision