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In our April issue of , Chris Aiken and David Liebers take a hard look at where these drugs really fit ( Highlights: , : GLP-1s can reverse antipsychotic weight gainsomething metformin rarely achieves once weight is established

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A study of adults with diabetes suggests patients with obstructive sleep apnea derive a 20% greater mortality reduction from GLP-1 therapy than those without the sleep disorder.

Approaches such as simultaneous low-dose initiation, careful titration, and close monitoring can help manage tolerability concerns and improve adherence to ARNI therapy