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2011b;25(7):133341

A head-to-head comparison revealed that both semaglutide and tirzepatide reduced the composite risk of hospitalization for HF or all-cause mortality by over 40% relative to placebo, with no significant advantage of tirzepatide over semaglutide

Other important safety considerations include: Risk of acute pancreatitis : Seek urgent medical attention for severe, persistent abdominal pain with or without vomiting [1] Gallbladder disease : Increased risk of gallstones and related complications Diabetic retinopathy : Caution in patients with pre-existing retinopathy due to rapid improvement in blood glucose control Hypoglycaemia : Increased risk when used with insulin or sulfonylureas, which may require dose reduction of these medications Oral contraceptive interaction : Reduced effectiveness due to delayed gastric emptying

doi: 10.1038/nature05026

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