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Consider reducing doses of these medications and intensify glucose monitoring to prevent hypoglycemia when initiating semaglutide

According to current therapeutic guidelines, the recommended pharmacological regimen for HFpEF should include SGLT2i (empagliflozin), mineralocorticoid receptor antagonists (spironolactone), angiotensin receptor-neprilysin inhibitors (sacubitril/valsartan), and angiotensin II receptor blockers (candesartan) [25]

Semaglutide is a pharmacological substitute for natural diabetes hormone