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It helps with pacing

Work with your provider to develop a transition plan that may include dose adjustment, temporary discontinuation, or switching to alternative approaches

Lancet Diabetes Endocrinol 2016;4:1004-16.ArticlePubMed 121

McGraw-Hill / Lange rxlist.com (Glyset ) Keywords DPP-4 Inhibitors Sitagliptin Trade Name: Januvia Drug Class: oral hypoglycemics Mechanism of Action: An inhibitor of dipeptidyl peptidase-4 (DPP-4), a protease that degrades the incretin GLP-1 Incretins are hormones released from the GI tract in response to nutrient ingestion Incretins potentiate glucose-stimulated insulin secretion from beta cells in the pancreas As a result of inhibiting DPP-4, increased or prolonged GLP-1 levels are able to potentiate the secretion of insulin by the pancreas The effect produced by DPP-4 inhibitors is dependent on endogenous GLP-1 levels, and produce a modest effect on GLP-1 activity compared to giving GLP-1 receptor agonists (hence DPP-4 inhibitors do not have the same impact to produce weight loss as GLP-1 agonists)

We havent had a good treatment for metabolic-associated liver disease, and so this is something which actually can help reduce visceral fat accumulation. However, because GLP-1 drugs are still fairly new in widespread use, some questions remain