glp 1 drugs vs phentermine Wegovy vs. phentermine: Differences, similarities & side effects Pharmacology: Weight Loss Medications, Mechanisms
Description
Participants treated with liraglutide (239), semaglutide (240), or tirzepatide (200) in the clinical trials had a percent reduction in fat mass approximately three times greater than the reduction in lean mass, leading to an overall improvement in body composition

Not everyone needs the maximum dose

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Even though the oral dose is higher, only a tiny fraction actually enters the bloodstream

Nausea ranged from approximately 11% at the lowest 1 mg dose to 64% in some intermediate-dose arms, with about 33% in the 9 mg fixed-dose (highest-efficacy) arm
