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Exenatide once weekly versus placebo in Parkinson's disease: A randomised, doubleblind, placebocontrolled trial

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Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications primarily prescribed for the management of type 2 diabetes mellitus and, more recently, for weight management in adults with obesity

Unlike in the pancreas, the gene product, (pre)proglucagon, is processed here to release the two glucagon-like hormones, GLP-1 and GLP-2, 2 whereas the glucagon sequence is buried in an N-terminal fragment of proglucagon called glicentin

demonstrated that in neuronal cells that tirzepatide activates Akt/CREB/BDNF pathway and the downstream signaling cascade counteracting hyperglycemia and insulin resistance-related damage at the neuronal level (51)