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The effect on stroke is remarkable (and was significant in the trials of both semaglutide and dulaglutide), amounting to an 18% risk reduction, also because the other class of new antidiabetic agents with cardiovascular benefits, the SGLT2-inhibitors, show no a similar effect on stroke (but do have a significant effect on heart failure) [24]

Summary: Retatrutide may cause acid reflux symptoms in some individuals due to its slowing of gastric emptying via GLP-1 receptor activation, though a definitive causal link has not yet been formally established

Early studies show promise, but more human research is needed

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He has created a library of DPP-IV resistant peptides that bind at the receptor sites