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Dula also significantly reduced the expression of transforming growth factor-1 (TGF-1), phosphatidylinositol-3-kinase (PI3K), protein kinase B (AKT) signaling pathway, and the inflammatory cytokines: nuclear factor kappa B (NF-B), interleukin-6 (IL-6), and interferon- (IFN-) in colonic cellular structures

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Compared to sitagliptin, GLP-1 analogues are more effective in reducing HbA1C (weight mean difference 0.41%, 95% CI 0.51 to 0.31) and body weight (weight mean difference 1.55 kg, 95% CI 1.98 to 1.12)
