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Excluded from this analysis were clinical trials involving animals or healthy humans, nonrandomized trials, RCTs shorter than 12 weeks, retrospective studies, pooled analyses of clinical trials, conference proceedings, letters to editors, case reports, and articles that lacked relevant data on the outcomes of interest

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The Novo Nordisk Foundation Center for Protein Research is supported financially by the Novo Nordisk Foundation (grant number NNF14CC0001)