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Traditional recommendations have called for the use of stepwise addition of medications to metformin to maintain A1C goals

While Rybelsus is a GLP-1 receptor agonist, Mounjaro acts as a dual GIP and GLP-1 receptor agonist, which may provide enhanced weight loss and glucose control benefits

Three weeks later, mice were terminally anaesthetised with 100 mg/kg pentobarbital and transcardially perfused with PBS containing 4% PFA, brains were collected, post-fixed in 4% PFA at 4 C overnight and cryoprotected in 30% sucrose for 23 days

Volkova, A., Shadrina, M., Kolomin, T., Andreeva, L., Limborska, S., Myasoedov, N., & Slominsky, P

GLP-1 stands for glucagon-like peptide-1, a gut hormone pathway linked with appetite and insulin response