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Newer agents appear to be more effective at A1c and weight lowering, and its a very exciting time for the treatment of type 2 diabetes and obesity when the new GLP-1 agonists are able to achieve more robust A1c lowering than any other existing diabetes medication other than insulin, she told Healthline

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In HEK293 cells expressing human GIP receptor or GLP-1 receptor, tirzepatide potently stimulated cAMP accumulation by both receptors, and the potency of tirzepatide was similar to that of native GIP and approximately 13-fold weaker than that of GLP-1 in these assays [88]

Lee: There is growing interest in how GLP-1 medications may influence the brains reward system, particularly dopamine signaling