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Larger reductions in A1c were generally seen with higher doses of SGLT2-I and amongst patients with higher baseline A1c values

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A glycine at the second N-terminal position protects the molecule from DPP-4 inactivation while a glutamic acid at position 16 stabilizes the secondary structure and improves potency

SOURCE: NuraPatch Source: NuraPatch

Unlike semaglutide, which targets only the GLP-1 receptor, tirzepatide is a dual-action medication that activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors