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The FDA states that exenatide, the first GLP-1 receptor agonist, is being phased out as of January 2025 due to a GLP-1 scarcity
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doi: 10.1016/j.cbi.2024.111030 172 XiaoSLiuNYangXJiGLiM

2025) showed that combining semaglutide with GDF8/activin A blockers preserved lean mass and enhanced fat loss in preclinical models

The FDAs accelerated approval was supported by data from the Phase II MagnetisMM-3 study, which found that in heavily pretreated RRMM patients who had not yet received BCMA-directed therapy, Elrexfio had an overall response rate of 58%, with around 82% of responders maintaining improvements for at least nine months
