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doi:10.1016/j.molmet.2018.05.014 52

With this degree of weight loss in only 48 weeks, we see people having improvement or resolution in other conditions like hypertension, hyperlipidemia, osteoarthritis, sleep apnea, and more weight-related conditions, Billings said
Clinicians should set expectations accordingly and individualize treatment duration based on therapeutic response, tolerability, and long-term management goals

These results taken together suggest that adding even mild amounts of GR agonism (to increase energy expenditure) on top of a dual agonist like Tirzepatide is able to produce even more pronounced decreases in weight