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Description
A key differentiator of CT-388 lies in its design to produce potent activity on both the GLP-1 and GIP receptors, along with minimal-to-no -arrestin recruitment on either receptor

The Food and Drug Administration (FDA) has approved Eli Lillys once-daily oral GLP-1 receptor agonist, orforglipron, for adults with obesity, or overweight with weight-related medical problems

Inhibition of mitochondrial complex I improves glucose metabolism independently of AMPK activation

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PLOS Medicine [Internet]
