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The physiological or therapeutic significance of GLP-1 RA engagement at these peripheral sites remains unclear and warrants further investigation

The success of semaglutide has also intensified the pharmaceutical race other companies are developing their own GLP-1 approaches (for instance, Eli Lillys oral non-peptide GLP-1 agonist orforglipron is in late-stage trials, expected to file for FDA approval in 2026)

To qualify for the Medicare GLP-1 Bridge program, patients must be classified as obese, meaning they have a body mass index (BMI) of 30 or greater