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The GLP-1 NAION vision-loss MDL hit 146 cases on the July JPML report up 70% in two months as the GI-injury MDL heads to Rule 702 hearings September 10-18.

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In these Ghsr+Glp1r+ neurons, ghrelin preadministration abolished the GLP-1-induced calcium response

In most major obesity trials, GLP-1 therapy was: Escalated to high or maximum tolerated doses Stopped abruptly, not down-titrated Followed by little or no continuation of structured lifestyle support In the STEP-1 extension trial (semaglutide 2.4 mg), participants who discontinued therapy regained approximately two-thirds of their prior weight loss over the following year