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At the same time, overall spending on GLP-1 drugs has grown substantially, with national pharmacy spend rising more than 500 % from 2018 to 2023, underscoring the economic impact on payers and employers alike

About 7% of participants taking Wegovy dropped out due to adverse events (versus 3% with placebo)

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GLP-1 Rs are abundantly expressed on stomach-innervating vagal afferent neurons which are critical for detecting gastrointestinal stretch and transmitting this information to the nucleus tractus solitarius (NTS

[00:08:23.390] Well, David, weve had conversations at Lid with with retail, North American-based retailers, global in scale, some of them, who, when theyre thinking about their Canadian supply chain, are asking themselves, well, if Im going to renew my Canadian infrastructure and put a large facility and put a large amount of capital into the greater Toronto area, and Im going to have a Canadian e-commerce operation anyway, why not greatly expand grant that operation and run my entire North American e-commerce operation there because the de minimis loophole allows me to