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Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM

This study showed that use of GLP-1 RAs was not associated with increased incidence of suicide or suicide attempts in either the active comparator new-user design or in the self-controlled case series design

These supplements are not as intense as GLP-1 medications, however, some contain ingredients that increase GLP-1 production in the body

Furthermore, a recent clinical study in women with obesity treated with semaglutide showed improved recognition of basic tastes, altered gene expression in the tongue (measured by tongue biopsy), decreased activation of putamen in response to calorie-dense sweet and savory food cues, and increased cortical brain activity in response to the sweet taste stimulus compared to placebo