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Most importantly, microdosing does not have established evidence as an Alzheimers prevention strategy

The weight-loss benefit is real, the approved versions are expensive or unavailable, and telling someone the gray market is dangerous does not change the math that drove them to it

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After the FDA declared GLP-1 shortages resolved in early 2025 and began cracking down on compounding pharmacies, Ro and Hims & Hers shifted to partnering with Eli Lilly and Novo Nordisk's direct-to-consumer cash-pay pharmacies, LillyDirect (launched January 2024) and NovoCare (launched March 2025), that the manufacturers had built to bypass insurance and PBM channels and capture the unprecedented consumer demand around by GLP-1s, for which ~60% of patients are denied coverage by their insurers

Simultaneously, NAD+ levels increased by 1.2 to 1.6 fold compared to untreated cells