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The medication's effectiveness depends on proper dosing and adherence, not on side effect severity

This binding event triggers a rapid intracellular signaling cascade, causing a localized influx of calcium that forces the L-cells to secrete GLP-1 and Peptide YY (PYY) into the systemic bloodstream

Persistent nausea beyond the standard 48 week adaptation window may require dose reduction or switching to tirzepatide

As of January 2026, only 13 state Medicaid programs covered GLP-1s for obesity treatment

A clinical trial found patients lost 20% of their body weight in 16 months while using tirzepatide, but the FDA has not yet approved it for weight loss although it can be used for this purpose off-label