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In AD mouse models, pathophysiological changes, such as anti-apoptotic effects, reduced A deposition and phosphorylated hippocampal tau, protection from synapse loss, reduced inflammatory and oxidative stress response in the cortex and hippocampus, and increased BDNF have been observed [119,120,121]
An exploratory 12-month follow-up study in patients with PD (NCT03456687) comparing exenatide with placebo has been completed, although its results remain unpublished
Antipsychotics and glucose metabolism: how brain and body collide
The side effect profile of DPP-4 inhibitors is favorable, there are few treatment-limiting adverse effects and DPP-4 inhibitors have shown cardiovascular safety
Her background is in clinical pharmacy, and now she's an obesity director at Novo Nordisk
