glp 1 dopamine GLP-1 receptor agonists are going to be the first medications that treat polysubstance use disorder. Not one drug class at a time. All of them. Cocaine, methamphetamine, nicotine, alcohol, opioids… GLP‐1 Receptor Agonists for Treating
Description
In ovarian granulosa cells, hypermethylation of the steroidogenic enzyme cytochrome P450 family 19 subfamily A member 1 (CYP19A1) promoter reduces estrogen biosynthesis while relatively increasing androgen production, thereby exacerbating hyperandrogenemia (52)

N Engl J Med 398:205216

On the other hand, TIIDM is characterized by an imbalance between insulin levels and insulin sensitivity, resulting in persistent hyperglycemia

N Engl J Med 2021;384:1113-24.ArticlePubMed 120

HendersonSJKonkarAHornigoldDCTrevaskisJLJacksonRFritsch FredinMet al