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18 Although the metabolite does not induce insulin release or glucose metabolism, 19 a potential role was suggested for inhibiting hepatic glucose production in an insulin-resistant state of obesity
[DOI] [PubMed] [Google Scholar] 223.Ye J., Hao Z., Mumphrey M.B., Townsend R.L., Patterson L.M., Stylopoulos N

The phase III SURMOUNT-3 trial by Thomas et al207 evaluated tirzepatide use following intensive lifestyle interventions

Appetite Regulation: Effective appetite regulation is essential for maintaining a healthy diet and achieving weight loss or management goals

Response can be weight change, it can be change in waist circumference or body composition (the ratio of fat mass to lean mass), Crotty says
