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Efficacy and weight change are approximate averages from clinical trials
This is also probably a combination of glucagon and GIP agonism contributing to changes in certain background proteins, specifically lipoprotein lipase, ANGPTL 3 / 8 complexes and ApoC3 as shown in other studies

Yaribeygi H, Maleki M, Butler AE, et al

Neuropsychopharmacology 40 , 19691978 (2015)

While there is good reason to be hopeful that generic versions will be available in coming years, for now the out-of-pocket costs make long-term use inaccessible for most people
