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Freezing can cause the peptide to denature, rendering it ineffective

doi: 10.1007/s11695-023-06484-8 30 KristensenSLRrthRJhundPSDochertyKFSattarNPreissDet al

Marketed under the brand name Mounjaro, tirzepatide represents a significant advancement in incretin-based therapies, offering dual agonist activity that distinguishes it from single GLP-1 receptor agonists such as semaglutide or liraglutide

This suggests aggregation, where peptide molecules have clumped together and fallen out of solution

For persistent or severe symptoms, healthcare providers may consider temporarily interrupting treatment or reducing to a previously tolerated dose