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In phase 3 trials, maximal dose retatrutide demonstrated 29% placebo-adjusted weight loss at 68 weeks (albeit with higher discontinuation rates than semaglutide and tirzepatide)

Clinical data shows lean mass can account for roughly 20-40% of total weight lost on these medications

Pottegard A, Schmidt SAJ, Wallach-Kildemoes H, Sorensen HT, Hallas J, Schmidt M

Emerging therapeutics targeting the PI3K/Akt/GSK-3 in calcium dysregulation in Alzheimers disease

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