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Some brands of oral semaglutide, such as Rybelsus, contain the absorption enhancer salcaprozate sodium, which may enter milk and accumulate in infants

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In a large randomized withdrawal trial, participants who stopped tirzepatide after substantial initial weight loss regained an average of 14% of their body weight over the following year, while those who continued treatment maintained or furthered their weight loss, with 89.5% keeping at least 80% of their initial weight reduction compared to only 16.6% in the placebo group[3]

The incidence of MBSH ranged significantly across different diagnostic methods: 2.666.4% (self-report), 6.661.8% (oral glucose tolerance test), 29.478.6% (mixed-meal tolerance test), and 5075% (continuous glucose monitoring)