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For example, one early protocol for substance uses disorders employed 500-1,000 mg of NAD+ per day delivered by slow intravenous infusion over several consecutive days

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Due to lack of stratified data by time points across studies, we were unable to perform a subgroup analysis based on duration of treatment, which limited our ability to evaluate time-dependent risk trends of gastrointestinal adverse events

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Several 20242025 systematic reviews and meta-analyses have compiled the cross-trial safety data set (PMID 39318607, PMID 40291085, PMID 40728138)

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