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In addition, GLP-1R can be continuously activated to activate cAMP and P38 (94) and inhibit the conduction of the AKT and ERK1/2 signaling pathways ( in vivo and inducing the apoptosis of human pancreatic cancer cells in vitro ( 95)

Liraglutide administration did not reduce general food intake during baseline or produce motor suppression, highlighting behavioral specificity

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Both treatments can affect blood glucose levels and cause gastrointestinal side effects, which may be intensified when used together, particularly in patients with diabetes taking insulin or sulfonylureas

The STEP-9 trial showed patients with knee osteoarthritis taking semaglutide experienced marked improvements in pain scores along with significant weight reduction 39