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Patients should contact their healthcare provider if they experience severe or persistent heartburn that does not respond to conservative measures or over-the-counter treatments within 1-2 weeks, as this may indicate more significant gastroesophageal pathology requiring investigation

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[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Shirazi R.H., Dickson S.L., Skibicka K.P