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2022Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes

2025 Oct 16;9:25424823251388650

After 72 weeks, people taking tirzepatide lost over 20% of their body weight and shaved over 7 inches off their waistlines

Rosenstock J, Frias J, Jastreboff AM, et al

According to Rubino, clinical trials are now being planned to assess whether higher doses of GLP-1 drugs can be used in the acute phase to help patients lose weight, followed by lower "maintenance" doses, which come with fewer side effects and can be prescribed on a long-term basis