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However, there is limited experience in patients with severe renal impairment or end-stage renal disease, so caution is advised

Since pharmacokinetic data of the short-acting formulation of Ex applied in the present study is only available for rodents [35] and humans [36] (but not rhesus macaques), the timing of the drug administration and the two sessions was determined based on the behavioural findings of Scott and Moran [22], where the dose-dependent anorectic effects of Ex in rhesus macaque operant food consumption was seen up to 6 h post-administration

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This dual benefit of glycemic control and weight reduction has driven its popularity, further boosting the segment expansion