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El-Shewy HM, Lee MH, Obeid LM, Jaffa AA, Luttrell LM (2007) The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells

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A 2019 study in Nature Communications confirming MOTS-c\s role in exercise-induced metabolic signaling and its effects on glucose regulation and fat oxidation supports the clinical rationale at Perfect B for stacking MOTS-c with NAD+ in patients with insulin resistance or visceral fat accumulation

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