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As with all investigational agents, dosing recommendations may be refined as further Phase 3 data become available and regulatory submissions are made

The Phase 2 trial did include lower-dose groups (1mg, 4mg, 8mg), all of which showed meaningful weight loss, just less than the 12mg group

Encouragingly, in the retatrutide 12 mg escalation group, individuals showed up to ~17% bodyweight reductions at 36 weeks, a magnitude of reduction not documented till date in any other phase II\ III trials testing GLP-1 and GLP-1 receptor agonists in people with T2D

The Phase 2b MARIPOSA trial evaluated oral bedtime doses of AD109 in adults with mild to severe OSA and included patients with or without obesity and those with or without prior use of PAP therapy