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Major medical organizations, including the American Diabetes Association and the Obesity Society, recognize GLP-1 therapy as an ongoing treatment for weight maintenance, not a short-term intervention

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Dose timing after significant weight loss As you lose weight, your body composition changes

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54 Data from two larger, Phase II trials are due in the coming months

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Current FDA labels document these patterns in detail: Wegovy (semaglutide) lists nausea (44% vs 16% placebo), vomiting (25% vs 6%), diarrhea (30% vs 16%), constipation (24% vs 11%), abdominal distension and eructation, with severe GI events in 4.1% versus 0.9% placebo.[2] Zepbound (tirzepatide) lists nausea, diarrhea, vomiting, constipation, abdominal pain, dyspepsia, eructation, and gastroesophageal reflux disease among common adverse reactions, with severe GI disease as a Warnings and Precautions item.[3] Both labels include postmarketing reports of ileus, severe constipation including fecal impaction, and acute kidney injury related to dehydration from severe GI symptoms

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Targeting the PI3K/AKT/mTOR signaling axis PTEN/PI3K/AKT/mTOR signaling Inactivation of PTEN (phosphatase and tensin homologue) by deletion or mutation has been identified in ~20% of primary PCa and approximately 35% of CPRC cases (Fig

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