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The non-coded amino acid residues incorporated at positions 2, 20, and 13 provide resistance to enzymatic degradation while maintaining receptor-binding affinity across all three target receptors

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3739 While it is encouraging that the weight loss achieved with GLP-1/GIPGLP-1 receptor agonists approaches levels typically seen after bariatric procedures such as gastric bypass or sleeve gastrectomy, the rapid regain of a significant portion of the lost weight after treatment discontinuation, accompanied by a reduction in lean body mass, raises new clinical concerns