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Dosing typically ranges from 5 to 10 grams between meals or around training

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11 Unlike HFrEF, which is characterized by loss of contractile myocardium with localized replacement fibrosis typically following myocardial infarction, HFpEF features diffuse interstitial and perivascular fibrosis that reflects chronic metabolic and hemodynamic stress rather than direct myocardial injury

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