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The lifestyle guidance was based on U.S

Avoid injecting two medications in the exact same spot

The medication itself may also be compromised

Sources: OASIS 4 (Wharton et al, NEJM 2025), SURMOUNT-1 (Jastreboff et al, NEJM 2022), COR programme trials, NICE TA875/TA664

Infusion maintains a steady-state drug concentration in the bloodstream, which is crucial for studying pharmacokinetics without the fluctuations seen with bolus dosing
