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Similarly, semaglutide ameliorates doxorubicin-induced cardiotoxicity by reducing BNIP3-mediated mitochondrial dysfunction through the PI3K/AKT pathway, enhancing mitochondrial function and reducing cardiac injury (Li et al., 2024), potentiating its clinical application in cardiovascular diseases
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Diabetes status affects results modestly
GLP-1RAs showed significantly more reduction of cardiovascular endpoints than other second- or third-line glucose-lowering medications
As the dose gradually increases over time, the appetite-suppressing effects tend to become more pronounced
