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Clinical trials show GLP-1 agonists produce significantly greater weight losstypically 1522% of body weight over 68 weekscompared to phentermine's effects

In previous large-scale clinical trials of GLP-1RAs, 15.2% ( n = 618) of AMPLITUDE-O and 6.1% ( n = 575) of Harmony Outcomes patients used SGLT2is at baseline [18, 20] (Table 1)