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It can also lead to increased pain and bruising
PlexusDx Precision Peptide Genetic Test identifies variants in GLP1R, MC4R, FTO, and GIPR genes that predict your cardiovascular response to semaglutide

Does insulin resistance make semaglutide less effective

Semaglutide is contraindicated in patients with personal or family history of medullary thyroid cancer and should be used cautiously in those with severe kidney disease or acute pancreatitis

A separate trial tested semaglutide specifically in patients with cirrhosis and found it did not significantly improve fibrosis in that group