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Kolterman OG, Kim DD, Shen L, Ruggles JA, Nielsen LL, Fineman MS, et al

These categories included genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication [2]

Effects of GLP-1 Receptor Agonists on RAAS GLP-1 receptor agonists (GLP1-RA) are a relatively novel class of anti-diabetic drugs that improve glycemic control by potentiating the physiological effect of the gut hormone GLP-1 (59)

Growth of the segment has been attributed to strong clinical outcomes associated with this class of drugs, including improved glycemic control, reduced appetite, and significant weight reduction

Patients should never discontinue or adjust medications without provider guidance, as abrupt changes can lead to worsening or uncontrolled blood pressure or loss of glycemic control